99586-26-2

Product Name2-Bromo-7-chloro-9h-fluorene
Purity99%

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Product Details

Quick Details

CasNo： 99586-26-2
Purity： 99%

99586-26-2 Properties

Molecular Formula:C₁₃H₈BrCl
Molecular Weight:279.564
Melting Point:156-157 °C
Boiling Point:386.8±35.0 °C(Predicted)
Density:1.584±0.06 g/cm3(Predicted)

99586-26-2 Process route

: 6638-60-4
2-amino-7-bromofluorene

: 99586-26-2
2-bromo-7-chloro-9H-fluorene

Conditions

Conditions	Yield
With hydrogenchloride; Diazotization_.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver;

: 99586-26-2
2-bromo-7-chloro-9H-fluorene

: 1256388-51-8
methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium hexamethylsilazane; N-fluorobis(benzenesulfon)imide / di-isopropyl ether / 2.5 h / -65 °C / Inert atmosphere 2.1: potassium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl acetamide / 5 h / 120 °C / Inert atmosphere 3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Inert atmosphere 4.1: hydrogen bromide / acetone / 6 h / 75 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C 5.2: 3 h / 0 - 20 °C With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; palladium diacetate; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; N-fluorobis(benzenesulfon)imide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; dichloromethane; di-isopropyl ether; N,N-dimethyl acetamide; acetone; 3.1: \|Suzuki Coupling;

Yield

Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane; N-fluorobis(benzenesulfon)imide / di-isopropyl ether / 2.5 h / -65 °C / Inert atmosphere

2.1: potassium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl acetamide / 5 h / 120 °C / Inert atmosphere

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Inert atmosphere

4.1: hydrogen bromide / acetone / 6 h / 75 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

5.2: 3 h / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; palladium diacetate; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; N-fluorobis(benzenesulfon)imide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; dichloromethane; di-isopropyl ether; N,N-dimethyl acetamide; acetone; 3.1: |Suzuki Coupling;

99586-26-2 Upstream products

6638-60-4
2-amino-7-bromofluorene

99586-26-2 Downstream products

605630-37-3
2-bromo-7-chloro-9,9-dimethyl-9H-fluorene
1256388-51-8
methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate