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85-43-8

  • Product NameTetrahydrophthalic anhydride
  • Molecular FormulaC8H8O3
  • Molecular Weight152.15
  • Purity99%
  • AppearanceWHITE CRYSTALLINE POWDER
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  • CasNo： 85-43-8
  • Molecular Formula： C8H8O3
  • Appearance： WHITE CRYSTALLINE POWDER
  • Purity： 99%

Good Supplier Export Industrial Grade 99% Tetrahydrophthalic Anhydride 85-43-8 Intermediates White Crystalline In Stock with Best Price, Fast Delivery

  • Molecular Formula:C8H8O3
  • Molecular Weight:152.15
  • Appearance/Colour:WHITE CRYSTALLINE POWDER 
  • Vapor Pressure:0.001mmHg at 25°C 
  • Melting Point:101-102 °C 
  • Refractive Index:1.529 
  • Boiling Point:305.6 °C at 760 mmHg 
  • Flash Point:148.2 °C 
  • PSA：43.37000 
  • Density:1.289 g/cm3 
  • LogP:0.65220 

Tetrahydrophthalic Anhydride 85-43-8 Usage

Description Tetrahydrophthalic Anhydride (THPA) is a cyclic dicarboxylic anhydride, typically encountered in its cis isomer form, derived from tetrahydrophthalic acid. It appears as a white crystalline solid or as a clear, colorless to light yellow viscous liquid. This compound is insoluble in water, denser than water, and highly corrosive, posing significant health hazards as an irritant to the skin, eyes, and mucous membranes.
Physical Properties

THPA appears as a white crystalline powder. It is insoluble in water and denser than water. This compound is very irritating to the skin and eyes.

Definition

ChEBI: 1,2,3,6-tetrahydrophthalic anhydride is a cyclic dicarboxylic anhydride that is 1,3,3a,4,7,7a-hexahydro-2-benzofuran carrying oxo groups at positions 1 and 3. It is a cyclic dicarboxylic anhydride and a tetrahydrofurandione.
Uses THPA is widely utilized as an intermediate in the production of polyesters, plasticizers, adhesives, and pesticides, and it serves as a hardener for resins. Additionally, it plays a crucial role in the manufacture of polyester and alkyd resins. Due to its versatile reactivity, it is integral in various industrial applications, particularly in the synthesis of high-performance materials and coatings.
Toxicity and Corrosiveness THPA is highly toxic and corrosive. It can cause irritation to the skin, eyes, and mucous membranes. It is also corrosive to both the skin and metals.
Storage and Handling THPA must be stored away from open flames or potential ignition sources. It is sensitive to moisture, and crystallization can occur in contact with humid air.
Canonical SMILES C1C=CCC2C1C(=O)OC2=O
XLogP3-AA 0.8
Complexity 218
Precursors to Other Compounds

THPA is a precursor to other compounds, including tetrahydrophthalic acid and tetrahydrophthalimide. Tetrahydrophthalimide is further used in the synthesis of the fungicide Captan.

Hazard

Strong irritant to eyes and skin.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Nonflammable

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame. Will react with water or steam to produce heat; can react with oxidizing materials. To fight fre, use water, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.

InChI:InChI=1/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1,3,5-6H,2,4H2

85-43-8 Relevant articles

Electron paramagnetic resonance study of the paramagnetic center in gamma-irradiated tetrahydrophthalic anhydride single crystal

Ali Cengiz Caliskan

Radiation Effects and Defects in Solids Incorporating Plasma Science and Plasma Technology Volume 175, 2020 - Issue 11-12

Electron Paramagnetic Resonance (EPR) analysis of gamma-irradiated tetrahydrophthalic anhydride (C8H8O3) single crystals was performed at 120 K. The single crystals were exposed to 60Co-gamma source at room temperature. The EPR spectra of gamma-irradiated single crystals of tetrahydrophthalic anhydride (THPA) were recorded at 10-degree intervals for different orientations of crystals in a magnetic field.

Cross-Linked Networks in Poly(propylene carbonate) by Incorporating (Maleic Anhydride/cis-1,2,3,6-Tetrahydrophthalic Anhydride) Oligomer in CO2/Propylene Oxide Copolymerization: Improving and Tailoring Thermal, Mechanical, and Dimensional Properties

Meiying Huang, Lijun Gao*, Jiuying Feng, Xuyi Huang, Zengquan Li, Zetian Huang, and Lingyun Wang

ACS Omega 2020, 5, 28, 17808–17817

Herein, we focus on improving these properties. A (maleic anhydride/cis-1,2,3,6-tetrahydrophthalic anhydride) (MA/THPA) oligomer containing several cyclocarboxylic anhydride groups, which can copolymerize with PO, has been readily synthesized and used as the third comonomer to prepare PPC with cross-linked networks.

85-43-8 Process route

o-xylene
95-47-6

o-xylene

dimethyl cyclohex-4-ene-1,2-dicarboxylate
7500-55-2

dimethyl cyclohex-4-ene-1,2-dicarboxylate

3,4-dimethoxycarbonylcyclohexyl-3′,4′-dimethylbenzene
1352221-13-6

3,4-dimethoxycarbonylcyclohexyl-3′,4′-dimethylbenzene

1,2,3,6-Tetrahydrophthalic anhydride
85-43-8

1,2,3,6-Tetrahydrophthalic anhydride

Conditions
Conditions Yield
With Tridecane; In methanol; at 180 ℃; for 2h; Reagent/catalyst; Concentration; Inert atmosphere;
92.2%
maleic anhydride
108-31-6

maleic anhydride

buta-1,3-diene
106-99-0,130983-70-9,29406-96-0,9003-17-2

buta-1,3-diene

1,2,3,6-Tetrahydrophthalic anhydride
85-43-8

1,2,3,6-Tetrahydrophthalic anhydride

Conditions
Conditions Yield
at 80 - 110 ℃; for 4h; Temperature; Large scale;
98.1%
 
 80%
With benzene; at 100 ℃;
 
With benzene; at 115 - 145 ℃;
 
With benzene; at 20 ℃;
 
In 1,4-dioxane; at 30 ℃; Yield given;
 
In 1,4-dioxane; at 30 ℃; Rate constant; Kinetics;
 
 
  
 
  
In neat (no solvent); at 30 ℃; for 2h; Green chemistry;
95.6 %Chromat.

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