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Article |
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Uses |
suzuki reaction. 4-Chloro-2-methoxyphenylboronic acid is a boronic acid derivative with specific substituents on the phenyl ring. Boronic acids are known for their utility in organic synthesis, particularly in reactions like Suzuki-Miyaura cross-coupling reactions. |
| Canonical SMILES | B(C1=C(C=C(C=C1)Cl)OC)(O)O |
| Exact Mass | 186.0255020 g/mol |
| Monoisotopic Mass | 186.0255020 g/mol |
| Complexity | 145 |
The invention belongs to the technical f...
The benefits and limitations of a simple...
A condensed-cyclic compound is represent...
A mixture of crude 3-[(4-chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide (174 mg), 4-chloro-2-methoxyphenylboronic acid (116 mg, 0.62 mmol) and K3PO4 (217 mg, 1.02 mmol) in dioxane/water (10:1, 10 mL) was degassed with a stream of nitrogen for 15 min.
2-bromo-5-chloroanisole
Trimethyl borate
(4-chloro-2-methoxyphenyl)boronic acid
| Conditions | Yield |
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2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; Inert atmosphere; Flow reactor;
Trimethyl borate; In tetrahydrofuran; hexane; at -30 ℃; Inert atmosphere; Flow reactor;
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98% |
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2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.666667h; Inert atmosphere;
Trimethyl borate; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
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73% |
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2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; at -80 ℃; for 1h;
Trimethyl borate; In tetrahydrofuran; at 20 ℃;
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70% |
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2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
Trimethyl borate; In tetrahydrofuran; hexane; at 20 ℃; for 24h;
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50% |
2-bromo-5-chloroanisole
(4-chloro-2-methoxyphenyl)boronic acid
| Conditions | Yield |
|---|---|
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2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
With triisopropyl borate;
With hydrogenchloride; In water; ethyl acetate;
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2-bromo-5-chloroanisole
Trimethyl borate
4-(4-chloro-2-methoxyphenyl)pyridine 1-oxide
2-[3-(4-chloro-2-methoxyphenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[1-methyl-1-(3-trifluoromethyl-phenyl)ethyl]-acetamide
(4-chloro-2-hydroxyphenyl)boronic acid
C25H25ClN4O2
CAS:126747-14-6
