868549-07-9

Product Name9,9-Dimethyl-7-(9h-9-carbazolyl)-2-bromofluorene
Purity99%

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Product Details

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CasNo： 868549-07-9
Purity： 99%

868549-07-9 Properties

Molecular Formula:C₂₇H₂₀BrN
Molecular Weight:438.366

868549-07-9 Relevant articles

Synthesis method of photoelectric material intermediate N-(7-bromine-9, 9-dimethyl fluorene-2-yl) carbazole

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, (2021/01/20)

The invention belongs to the field of organic synthesis, and relates to synthesis of a photoelectric material intermediate N-(7-bromine-9, 9-dimethyl fluorene-2-yl) carbazole. The method comprises thefollowing steps of coupling 4-carbazolylphenylboronic acid and 5-bromine-2-iodobenzoic acid methyl ester, generating a methylation product by using a Grignard reagent, and finally performing Friedel-Crafts reaction and cyclization by using aluminum trichloride to obtain a target product. According to the method, the reaction temperature is reduced, the selectivity of bromine and iodine is improved, the purity and yield are improved, and the yield reaches 87% or above. The cost is reduced, and the method is suitable for industrial production.

868549-07-9 Process route

: 419536-33-7
4-(carbazol-9-yl)phenylboronic acid

: 868549-07-9
9,9-dimethyl-7-(9H-9-carbazolyl)-2-bromofluorene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium fluoride dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide; tetrahydrofuran; water / 8 h / Inert atmosphere; Reflux 2: tetrahydrofuran / 4 h / 20 - 25 °C / Inert atmosphere 3: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C With aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Yield

Multi-step reaction with 3 steps

1: potassium fluoride dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide; tetrahydrofuran; water / 8 h / Inert atmosphere; Reflux

2: tetrahydrofuran / 4 h / 20 - 25 °C / Inert atmosphere

3: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C

With aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;