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Product Details
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Uses |
4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs. |
InChI: InChI=1S/C6H5IN4/c7-5-2-1-4-6(8)9-3-10-11(4)5/h1-3H,(H2,8,9,10)
The invention discloses a synthesis meth...
The invention discloses a preparation me...
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pyrrolo[2,1-f][1,2,4]triazin-4-amine
7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
| Conditions | Yield |
|---|---|
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
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95% |
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pyrrolo[2,1-f][1,2,4]triazin-4-amine; With Iodine monochloride; In N,N-dimethyl-formamide; at -25 - -10 ℃; for 3h; Inert atmosphere;
With N-iodo-succinimide; acetic acid; In N,N-dimethyl-formamide; at -10 ℃; for 1h; Reagent/catalyst; Solvent; Inert atmosphere;
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90% |
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pyrrolo[2,1-f][1,2,4]triazin-4-amine; With pyridine; iodine; In ethyl acetate; at 0 - 10 ℃; for 1h;
With dihydrogen peroxide; In ethyl acetate; at 20 ℃; for 10h;
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85% |
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
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81% |
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With iodine; urea hydrogen peroxide adduct; In ethanol; at 78 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;
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80% |
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
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77% |
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 3 - 8 ℃; for 4h; Large scale;
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76.1% |
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With N-iodo-succinimide; In dimethyl sulfoxide; at 20 ℃; for 16h;
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75% |
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With N-iodo-succinimide; potassium carbonate; In ethanol; at 15 - 30 ℃; for 24h; Large scale;
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70.8% |
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 5h;
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47% |
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
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With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
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With iodine; potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
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With N-iodo-succinimide; N,N-dimethyl-formamide; at 0 ℃; for 3h;
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30 g |
4-chloro-7-iodopyrrolo[1,2-f][1,2,4]triazine
7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
| Conditions | Yield |
|---|---|
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With ammonia; In tetrahydrofuran; methanol; at 20 - 55 ℃; for 18h;
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81% |
pyrrolo[2,1-f][1,2,4]triazin-4-amine
2-pyrrole aldehyde
1H-pyrrole-2-carbonitrile
pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one
7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
CAS:1762-84-1
CAS:159326-68-8
Molecular Formula:C6H6N4
Molecular Weight:134.14
