131274-22-1

Reaction

Air-stable, non-pyrophoric precursor of the Tri-t-butylphosphine ligand which is used in a variety of catalytic processes. Ligand for Suzuki cross-couplings. Ligand for Heck Reactions. Ligand for Stille Cross-couplings. Ligand for α-Arylation and vinylation of arylmandelic acid derivatives. Ligand for direct arylation of hetercycles Synthesis of benzocyclobutenes by C-H activation. Cross-coupling of Grignard reagents and aryl bromides. Palladium catalyzed annulation of haloanilines. Palladium-Catalyzed Acylation. Palladium Catalyzed Carbonylative Heck Reaction. Palladium-catalyzed aminosulfonylation. Palladium-catalyzed intramolecular C–O bond formation. Ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acid.

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reactionHindered Phosphine salt employed with a Pd(0)-15-membered, triolefinic, macrocyle in Suzuki cross-coupling reactions of aryl bromides and chlorides. Also used in Heck coupling of non-activated vinyl tosylates with electron deficient olefins.Ligand used in the Pd-catalyzed enantioselective α?arylation of N-boc-pyrrolidine.

Application

Tri-tert-butylphosphonium tetrafluoroborate is a ligand used in the palladium-catalyzed enantioselective alfa-arylation of N-boc-pyrrolidine. It is also used with a palladium(0)-15-membered, triolefinic, macrocyle in Suzuki cross-coupling reactions of aryl bromides and chlorides. Further, it is used in the Heck coupling of vinyl tosylates with olefins.